Medical research

The new gene therapy that could help save sight

A new gene therapy being developed at The Australian National University (ANU) will help people at risk of dry age-related macular degeneration (AMD) and could potentially save millions of people from going blind.

Oncology & Cancer

Researchers unlock mysteries of complex microRNA oncogenes

MicroRNAs are tiny molecules of nucleic acid that control gene expression, acting like a dimmer switch to tone down gene output at key positions in the network of information that governs a cell's function. MicroRNAs are ...

Psychology & Psychiatry

Overcoming PTSD: Study reveals memory disruption drug target

Fight or flight, panic, trembling: Our brains are wired to ensure we respond instantly to fear. While that fear response may save our lives in the dangerous moment, at times people stay on high alert long after the threat ...

Health

Why lack of sleep is bad for your heart

In recent years, numerous studies have shown that people who don't get enough sleep are at greater risk of stroke and heart attack.

Cardiology

Fingerprint of sleep habits as warning sign for heart disease

Chronic short sleep is associated with increased risk of clogged arteries, heart disease, and thus increased morbidity and mortality. New research in Experimental Physiology may have figured out why lack of sleep increases ...

Cardiology

Protecting damaged hearts with microRNAs

Once the heart is fully formed, the cells that make up heart muscle, known as cardiomyocytes, have very limited ability to reproduce themselves. After a heart attack, cardiomyocytes die off; unable to make new ones, the heart ...

Oncology & Cancer

New details revealed to explain how tumors recruit blood vessels

A study by University of North Carolina Lineberger Comprehensive Cancer Center researchers helps explain how tumors recruit blood vessels that provide fuel for their growth as well as an avenue for the tumors to spread.

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MicroRNA

In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression. They were first described in 1993 by Lee and colleagues in the Victor Ambros lab , yet the term microRNA was only introduced in 2001 in a set of three articles in Science.

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