Psychology & Psychiatry

Old antibiotic could form new depression treatment

An antibiotic used mostly to treat acne has been found to improve the quality of life for people with major depression, in a world-first clinical trial conducted at Deakin University.

Medical research

Researchers find drug combination may treat traumatic brain injury

Traumatic brain injury (TBI) is a serious public health problem in the United States. Recent data show that approximately 1.7 million people sustain a traumatic brain injury annually. While the majority of TBIs are concussions ...

Neuroscience

Antibiotic may be new stroke treatment

The antibiotic minocycline may revolutionize the treatment of strokes. A new study, published in the open access journal BMC Neuroscience, describes the safety and therapeutic efficacy of the drug in animal models.

Alzheimer's disease & dementia

Everyday drugs could combat dementia, according to major study

(Medical Xpress)—Medications used to treat hypertension, diabetes and skin conditions could be doubling as treatments for Alzheimer's within 10 years according to researchers. A groundbreaking new study funded by Alzheimer's ...

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Minocycline

Minocycline (INN) is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group. It is a bacteriostatic antibiotic, classified as a long-acting type. As a result of its long half-life it generally has serum levels 2-4 times that of the simple water-soluble tetracyclines (150 mg giving 16 times the activity levels compared to 250 mg of tetracycline at 24–48 hours).

Minocycline is the most lipid-soluble of the tetracycline-class antibiotics, giving it the greatest penetration into the prostate and brain, but also the greatest amount of central nervous system (CNS)-related side effects. These include vertigo and idiopathic intracranial hypertension (pseudotumor cerebri), and are significantly more common in female patients.

Due to poor urinary excretion, minocycline is a relatively poor tetracycline-class antibiotic choice for urinary pathogens sensitive to this antibiotic class, as its solubility in water, and levels in the urine, are less than all other tetracyclines.

Minocycline is not a naturally-occuring antibiotic, but was synthesized semi-synthetically from natural tetracycline antibiotics by Lederle Laboratories in 1972, and marketed by them under the brand name Minocin.

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