An antibiotic used mostly to treat acne has been found to improve the quality of life for people with major depression, in a world-first clinical trial conducted at Deakin University.
Jul 19, 2017
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An over-the-counter drug used to treat diarrhea combined with minocycline, an antibiotic used to treat bacterial infections, could one day change the lives of those living with cystic fibrosis.
Apr 24, 2011
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An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.
Nov 28, 2018
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During adolescence, sex hormones drive significant physiologic changes. One of the most universal and sometimes distressing experiences during adolescence is the development of acne, a skin condition that results from the ...
Nov 22, 2022
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Minocycline, an older, broad-spectrum antibiotic in the tetracycline family, provides meaningful improvements as a therapeutic for children with fragile X syndrome, a study by researchers at the UC Davis MIND Institute has ...
Apr 8, 2013
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(Medical Xpress)—Medications used to treat hypertension, diabetes and skin conditions could be doubling as treatments for Alzheimer's within 10 years according to researchers. A groundbreaking new study funded by Alzheimer's ...
Nov 1, 2012
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King's College London researchers have found evidence that minocycline, a widely used antibiotic with anti-inflammatory properties, gave greater improvement in depressive symptoms in patients with treatment resistant depression ...
Jan 28, 2021
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(Medical Xpress)—A new University of Sydney study has found that having Type 1 diabetes alters the normal communication between the human central nervous system and bone marrow, causing inflammatory effects and further ...
Oct 24, 2013
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For patients with treatment-resistant depression (TRD), minocycline as add-on to antidepressant treatment as usual does not reduce depressive symptoms, according to a study published online Sept. 14 in JAMA Network Open.
Sep 15, 2022
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A new study will help determine if an antibiotic is a partial antidote for the poisonous effect blood has on the brain following a hemorrhagic stroke, researchers say.
Apr 1, 2013
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Minocycline (INN) is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group. It is a bacteriostatic antibiotic, classified as a long-acting type. As a result of its long half-life it generally has serum levels 2-4 times that of the simple water-soluble tetracyclines (150 mg giving 16 times the activity levels compared to 250 mg of tetracycline at 24–48 hours).
Minocycline is the most lipid-soluble of the tetracycline-class antibiotics, giving it the greatest penetration into the prostate and brain, but also the greatest amount of central nervous system (CNS)-related side effects. These include vertigo and idiopathic intracranial hypertension (pseudotumor cerebri), and are significantly more common in female patients.
Due to poor urinary excretion, minocycline is a relatively poor tetracycline-class antibiotic choice for urinary pathogens sensitive to this antibiotic class, as its solubility in water, and levels in the urine, are less than all other tetracyclines.
Minocycline is not a naturally-occuring antibiotic, but was synthesized semi-synthetically from natural tetracycline antibiotics by Lederle Laboratories in 1972, and marketed by them under the brand name Minocin.
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