Immunology

Answers to microbiome mysteries in the gills of rainbow trout

While many immunologists use mouse models to conduct their research, J. Oriol Sunyer of Penn's School of Veterinary Medicine has made transformational scientific insights using a very different creature: rainbow trout.

Oncology & Cancer

Designer probiotic treatment for cancer immunotherapy

Researchers at Columbia Engineering have engineered probiotics to safely deliver immunotherapies within tumors. These include nanobodies against two proven therapeutic targets—PD-L1 and CTLA-4. The drugs are continuously ...

Oncology & Cancer

Cancer cells alter protein production machinery to hasten metastasis

Hormone receptor-positive breast cancer can spread throughout the body via the bloodstream as circulating tumor cells, or CTCs, which eventually reach distal (remote) body sites to form metastatic tumors. An increase in ribosomes, ...

Diseases, Conditions, Syndromes

New mouse model for celiac disease to speed research on treatments

Researchers at the University of Chicago have developed the first truly accurate mouse model of celiac disease. The animals have the same genetic and immune system characteristics as humans who develop celiac after eating ...

Diseases, Conditions, Syndromes

New method predicts individual response to Ebola infection

Not everyone who catches Ebola dies of the hemorrhagic virus infection. Some people mount a robust immune defense and recover fully. Yet risk factors for susceptibility to infection and disease severity remain poorly understood.

Oncology & Cancer

New CAR-T target yields promising results for multiple myeloma

Too many patients with cancers like multiple myeloma relapse after treatment. This grim reality motivated researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) to try to improve the depth and durability ...

Oncology & Cancer

Combined drug treatment for lung cancer and secondary tumors

Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous ...

Medical research

Team tracks integrin's role in lung function

Beta-1 integrin, a critical component of epithelial extracellular matrix receptors, is essential for normal lung function in adulthood, researchers at Vanderbilt University Medical Center have discovered.

Immunology

Researchers discover way to prime cancer tumors for immunotherapy

A cancer tumor's ability to mutate allows it to escape from chemotherapy and other attempts to kill it. So, encouraging mutations would not be a logical path for cancer researchers. Yet a Mayo Clinic team and their collaborators ...

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