With the support of the National Institute on Drug Abuse, scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country.
Aug 29, 2018
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Investigators at the Stanford University School of Medicine and their collaborators at three other institutions have identified a novel compound that appears to exhibit painkilling power comparable to morphine but lacks that ...
Aug 17, 2016
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Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp down the body's pain response. But now, neuroscientists ...
Apr 30, 2015
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For the first time, scientists at the University of North Carolina School of Medicine and collaborators solved the crystal structure of the activated kappa opioid receptor bound to a morphine derivative. They then created ...
Jan 4, 2018
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A commercially available drug may help drastically reduce two side effects of opioid painkillers—a growing tolerance and a paradoxical increased sensitivity to pain—without affecting the drugs' ability to reduce pain, ...
Jan 17, 2017
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(Medical Xpress)—Women tend to become addicted to drugs and relapse faster than men, though the biological reasons are not completely clear. Now, investigators at the Nathan Kline Institute for Psychiatric Research and ...
Jan 30, 2015
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Opioids, such as morphine, are still the most effective class of painkillers, but they come with unwanted side effects and can also be addictive and deadly at high doses. Designing new pain-killing drugs of this type involves ...
Jun 14, 2013
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Nearly everyone who has tried to quit smoking says it's incredibly difficult, and the struggle is due in part to genetic factors. Now, a new study from the Raymond and Ruth Perelman School of Medicine at the University of ...
May 16, 2011
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Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However, whether the use of fentanyl is associated ...
Jun 14, 2022
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A targeted opioid that only treats diseased tissues and spares healthy tissues relieves pain from inflammatory bowel disease without causing side effects, according to new research published in the journal Gut.
Mar 31, 2021
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