Alzheimer's disease & dementia

'Skinny fat' in older adults may predict dementia, Alzheimer's risk

A new study has found that "skinny fat—the combination of low muscle mass and strength in the context of high fat mass—may be an important predictor of cognitive performance in older adults. While sarcopenia, the loss ...

Medical research

Stem cells restore function in primate heart-failure study

Researchers at UW Medicine in Seattle have successfully used human stem cells to restore heart function in monkeys with heart failure. The findings suggest that the technique will be effective in patients with heart failure, ...

Immunology

Chemotherapy-induced diarrhea traced to immune cells

Some 50 to 80 percent of cancer patients taking powerful chemotherapy drugs develop diarrhea, which can be severe and in some cases life-threatening. Their problems occur when contractions in the smooth muscle lining the ...

Cardiology

Getting to the heart of congenital cardiac defects

Heart defects are the most common type of birth defect, and can be caused by mutations in the gene CHD4. Researchers at the UNC School of Medicine have now revealed key molecular details of how CHD4 mutations lead to heart ...

Cardiology

New target for treating heart failure identified

Changes in cellular struts called microtubules (MT) can affect the stiffness of diseased human heart muscle cells, and reversing these modifications can lessen the stiffness and improve the beating strength of these cells ...

Cancer

Excess zinc in muscles contributes to wasting syndrome in cancer

It's estimated that nearly one-third of all cancer deaths are caused not by the cancer itself but by cachexia—a debilitating muscle-wasting syndrome that affects an estimated 80 percent of advanced cancer patients. Cachexia ...

Medical research

Polarized cells give the heart its fully developed form

When it first starts to develop, the heart is a simple tube. Reporting in the journal Nature Communications, researchers at MDC have now described how it forms itself into a its characteristic S-shape and how the ventricles ...

Neuroscience

Leg exercise is critical to brain and nervous system health

Groundbreaking research shows that neurological health depends as much on signals sent by the body's large, leg muscles to the brain as it does on directives from the brain to the muscles. Published today in Frontiers in ...

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