University of Oxford researchers have for the first time established a controlled human infection model for tuberculosis (TB) that infects people via the lungs—the way TB enters the body.
Apr 15, 2024
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Tuberculosis is the biggest infectious killer in the world, causing 1.2 million deaths every year. In common with other pneumonia types, tuberculosis can destroy the human lung as a result of excessive inflammation.
Apr 16, 2024
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Mycobacterium tuberculosis (MTB) is a pathogenic bacterial species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on the cell surface (primarily mycolic acid), which makes the cells impervious to Gram staining; acid-fast techniques are used instead. The physiology of M. tuberculosis is highly aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, MTB infects the lungs, causing tuberculosis.
The M. tuberculosis genome was sequenced in 1998.
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