Proteasomes are protein-degrading complexes that are important for cancer cell survival. Proteasome inhibitors are commonly used to treat diseases such as multiple myeloma and mantle cell lymphoma. Proteasomes have three ...
Dec 14, 2023
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For transplantation-eligible patients with newly diagnosed multiple myeloma, the addition of subcutaneous daratumumab combined with bortezomib, lenalidomide, and dexamethasone induction and consolidation therapy and with ...
Dec 13, 2023
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A new research paper was published in Oncotarget, entitled, "Plasma levels of BCMA-positive extracellular vesicles correlate to response and side effects in myeloma patients treated with belantamab-mafodotin."
Dec 7, 2023
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Multiple myeloma (MM) is one of the most formidable and deadly cancers known to man, with only 50% of patients surviving for more than five years after diagnosis.
Nov 28, 2023
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Multiple myeloma is still an incurable hematological malignancy. One of the reasons is that myeloma cells can be heterogenous and acquire resistance after anti-myeloma treatment. Immunotherapy is an attractive strategy to ...
Nov 17, 2023
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All cancer cells—even those within the same tumor—differ from each other and change over the course of a cancer disease. Scientists at Heidelberg University Hospital, the Medical Faculty in Heidelberg and the German Cancer ...
Nov 10, 2023
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A multicenter study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine shows how interactions between tumor cells and immune components of the microenvironment ...
Nov 9, 2023
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Patients with multiple myeloma treated with idecabtagene vicleucel, known as "ide-cel," a chimeric antigen receptor (CAR) T-cell therapy, had no difference in overall survival outcomes regardless of race and ethnicity, according ...
Oct 19, 2023
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Researchers from Uppsala University have revealed one of the mechanisms behind the growth of cancer cells in the blood cancer multiple myeloma. The study shows that the protein EZH2 interacts with a specific RNA molecule ...
Sep 29, 2023
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Patients with multiple myeloma (a blood cancer of plasma cells in the bone marrow) who also have diabetes have a reduced overall survival when compared to those without diabetes. But in a subgroup analysis, this difference ...
Sep 29, 2023
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