Medications

Life saving overdose-reversing drug still not being accessed

Despite now being available over the counter, take-home naloxone programs designed to be used by potential overdose witnesses to prevent opioid-related harms, are not being bought in increased numbers, according to the authors ...

Medications

Study shows dramatic increase in naloxone dispensing in Ohio

It's not an over-the-counter drug, but naloxone can now be dispensed by a pharmacist without a prescription in some states. Researchers have found it's made a huge impact on the number of prescriptions being dispensed in ...

Medical research

Bioelectronic implant could prevent opioid deaths

Researchers are developing a novel, implantable device that can sense the effects of a potentially fatal level of ingested opioids and then automatically and immediately deliver a life-saving dose of naloxone.

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Naloxone

Naloxone is an opioid antagonist drug developed by Sankyo in the 1960s. Naloxone is a drug used to counter the effects of opiate overdose, for example heroin or morphine overdose. Naloxone is specifically used to counteract life-threatening depression of the central nervous system and respiratory system. Naloxone is also experimentally used in the treatment for congenital insensitivity to pain with anhidrosis (CIPA), an extremely rare disorder (1 in 125 million) that renders one unable to feel pain. It is marketed under various trademarks including Narcan, Nalone, and Narcanti, and has sometimes been mistakenly called "naltrexate." It is not to be confused with naltrexone, an opioid receptor antagonist with qualitatively different effects, used for dependence treatment rather than emergency overdose treatment.

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