The structure and functions of the tip of migrating neurons remain elusive. A research group has found that the PTPσ-expressing growth cone senses the extracellular matrix and drives neuronal migration in the injured brain, ...
Mar 11, 2024
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Over a hundred years after the discovery of the neuron by neuroanatomist Santiago Ramón y Cajal, scientists continue to deepen their knowledge of the brain and its development.
Apr 19, 2023
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During brain development, neurons have to migrate long distances through complex environments until they reach their final destination. In order to find guidance, they must establish several interactions—which are still ...
Oct 18, 2022
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The correct development of the brain cortex is an essential process for the acquisition of correct cognitive skills. Reelin, a key extracellular protein in neuronal migration and synaptic plasticity, is determinant in this ...
Sep 14, 2022
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Promoting the signaling pathway of reelin, an essential extracellular protein for the neuronal migration and synaptic plasticity, could be an effective therapeutic strategy to counterbalance the main cognitive, biochemical ...
Jan 23, 2020
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Neurons are not randomly arranged in the human brain. In the cortex, they are organized in interconnected clusters with high intrinsic connectivity. This modular connectivity structure, in which clusters eventually serve ...
Oct 9, 2019
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The brain can discriminate over 1 trillion odors. Once entering the nose, odor-related molecules activate olfactory neurons. Neuron signals first accumulate at the olfactory bulb before being passed on to activate the appropriate ...
Oct 19, 2018
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Function and homeostasis of the brain relies on communication between its complex network of cells. Consequently, development of the different groups of cells in the brain needs to be coordinated in time and space. The group ...
Aug 23, 2018
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Ashleigh Schaffer, Ph.D., assistant professor of genetics at Case Western Reserve University School of Medicine, and a team of global genetics experts have discovered a genetic mutation and the faulty development process ...
Aug 9, 2018
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A team of researchers from several institutions in Japan has found that developing neocortex neurons in mammals undergo a morphological transition from a multipolar shape to a bipolar shape due at least partially to signaling ...
