Neuroscience

Cells in 'little brain' have distinctive metabolic needs

Cells' metabolic needs are not uniform across the brain, researchers have learned. "Knocking out" an enzyme that regulates mitochondria, cells' miniature power plants, specifically blocks the development of the mouse cerebellum ...

Neuroscience

Direct conversion of non-neuronal cells into nerve cells

In 2012, a team of scientists headed by Professor Benedikt Berninger first succeeded in reprogramming connective tissue cells present in the brain into neurons. Until now, however, it was completely unknown which intermediate ...

Parkinson's & Movement disorders

Conversion of brain cells offers hope for Parkinson's patients

Researchers at Karolinska Institutet have made significant progress in the search for new treatments for Parkinson's disease. By manipulating the gene expression of non-neuronal cells in the brain, they were able to produce ...

Genetics

How to rule a gene galaxy: A lesson from developing neurons

The human organism contains hundreds of distinct cell types that often differ from their neighbours in shape and function. To acquire and maintain its characteristic features, each cell type must express a unique subset of ...