Medical research

Oscillation in muscle tissue

When a muscle grows or a muscle injury heals, some stem cells develop into new muscle cells. A research team at the MDC led by Carmen Birchmeier has now described in the journal Genes & Development how this process is regulated ...

Oncology & Cancer

The immune system's supercell—how it matures

Natural killer cells (NK cells), play an important role in the body's defences against cancer and infections. Now, in a joint project, researchers at Lund University in Sweden, the University of Oxford, and Karolinska Institutet ...

Oncology & Cancer

A cancer therapy that inhibits the Notch signaling pathway

EPFL spin-off Cellestia Biotech has just been given the regulatory go-ahead to start clinical testing a molecule it has developed to treat cancers involving mutations of the Notch gene. The molecule is a ray of hope for the ...

Genetics

Controlling cell-fate decisions

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial ...

Oncology & Cancer

What can Frizzled7 reveal about breast cancer development?

A new study shows that Frizzled7 (FZD7), a protein present on human breast epithelial cells and a component of the Wnt signaling pathway is uniquely controlled by the Notch signaling pathway, both of which play key roles ...

Medical research

Zebrafish help to unravel Alzheimer's disease

New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain. A new study by scientists at ...

Medical research

New blood: Tracing the beginnings of hematopoietic stem cells

Hematopoietic stem cells (HSCs) give rise to all other blood cell types, but their development and how their fate is determined has long remained a mystery. In a paper published online this week in Nature, researchers at ...

Medical research

Cell signaling pathway linked to obesity, Type 2 diabetes

(Medical Xpress)—A Purdue University study shows that Notch signaling, a key biological pathway tied to development and cell communication, also plays an important role in the onset of obesity and Type 2 diabetes, a discovery ...

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