Medical research

The key to proper muscle growth

When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells. The same thing happens when an injured muscle starts to ...

Medical research

The role of Klumpfuss in intestinal cell differentiation

Stem cells are essential for homeostasis and cell renewal in organs like skin, lung or intestine. During the course of life, their function decreases steadily, making this decline a main factor for the development of age-associated ...

Medical research

Oscillation in muscle tissue

When a muscle grows or a muscle injury heals, some stem cells develop into new muscle cells. A research team at the MDC led by Carmen Birchmeier has now described in the journal Genes & Development how this process is regulated ...

Oncology & Cancer

The immune system's supercell—how it matures

Natural killer cells (NK cells), play an important role in the body's defences against cancer and infections. Now, in a joint project, researchers at Lund University in Sweden, the University of Oxford, and Karolinska Institutet ...

Oncology & Cancer

A cancer therapy that inhibits the Notch signaling pathway

EPFL spin-off Cellestia Biotech has just been given the regulatory go-ahead to start clinical testing a molecule it has developed to treat cancers involving mutations of the Notch gene. The molecule is a ray of hope for the ...

Genetics

Controlling cell-fate decisions

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial ...

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