Oncology & Cancer

Scientists kill cancer cells by 'shutting the door' to the nucleus

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes—large channels that control the flow of materials in and out of the cell nucleus—shrank ...

Oncology & Cancer

Nuclear gatekeeper could block undruggable prostate cancer targets

Certain molecular drivers of cancer growth are "undruggable—it's been nearly impossible to develop chemicals that would block their action and prevent cancer growth. Many of these molecules function by passing cancer-promoting ...

Immunology

Nuclear pore functions are essential for T cell survival

Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus—they play an essential role in the survival of T cells. A new study by Sanford Burnham Prebys Medical ...

Genetics

Multifunctional protein contributes to blood cell development

Like an actor who excels at both comedy and drama, proteins also can play multiple roles. Uncovering these varied talents can teach researchers more about the inner workings of cells. It also can yield new discoveries about ...

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