Certain molecular drivers of cancer growth are "undruggable—it's been nearly impossible to develop chemicals that would block their action and prevent cancer growth. Many of these molecules function by passing cancer-promoting ...
Aug 9, 2018
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24
Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus—they play an essential role in the survival of T cells. A new study by Sanford Burnham Prebys Medical ...
May 7, 2018
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Researchers are unraveling the crucial first 30 minutes of viral invasion into a human cell.
Mar 29, 2018
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3
Like an actor who excels at both comedy and drama, proteins also can play multiple roles. Uncovering these varied talents can teach researchers more about the inner workings of cells. It also can yield new discoveries about ...
Dec 21, 2017
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3
Researchers at Kanazawa University report in EMBO Reports about a new molecular mechanism regulating cellular fate of squamous cell carcinomas. Squamous cell carcinoma (SCC) is a lethal cancer arising from the stratified ...
Dec 19, 2017
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3
Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center—the nucleus—appear to be a ...
May 4, 2017
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Huntington's disease is an inherited brain disorder that is uniformly fatal, but researchers at Johns Hopkins believe they have made a big discovery about how the disease progresses that could lead to a way to stop it.
Apr 9, 2017
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Considerable evidence has indicated that the drug metformin, used for more than 50 years to treat type 2 diabetes, also can prevent or slow the growth of certain cancers; but the mechanism behind its anticancer effects has ...
Dec 15, 2016
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214
When a developing heart can't tell left from right, it can take a team of scientists from a host of disciplines to explain why. Yale pediatricians, geneticists, cell biologists, and imaging experts have identified a surprising ...
Sep 2, 2016
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1
A new study offers the first atomic-scale view of an interaction between the HIV capsid - the protein coat that shepherds HIV into the nucleus of human cells - and a host protein known as cyclophilin A. This interaction is ...
Mar 4, 2016
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