Genetics

Scientists may need to rethink how genomics impacts risk for OCD

Both rare and commonly observed differences in the DNA letters strung along a person's chromosomes can explain about a third of the risk for being diagnosed with obsessive-compulsive disorder (OCD), according to a new study ...

Oncology & Cancer

LIM domain only 1: One gene, many roles in cancer

Humans have long been plagued by a myriad of deadly cancers. Parallelly, they attempted different permutations and combinations of treatments to cure the disease. Attempts involving biomolecular targets have come to the fore ...

Oncology & Cancer

Study of NCOA3 yields novel findings of melanoma progression

For the first time, activation of nuclear receptor coactivator 3 (NCOA3) has been shown to promote the development of melanoma through regulation of ultraviolet radiation (UVR) sensitivity, cell cycle progression and circumvention ...

Diabetes

Genetically determined vitamin D levels not linked to T1DM

(HealthDay)—Genetically determined vitamin D levels do not appear to have a large effect on the risk for type 1 diabetes in Europeans, according to research published online Feb. 25 in PLOS Medicine.

Genetics

Induced pluripotent stem cells reveal causes of disease

Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex, rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory ...

Oncology & Cancer

Understanding the DNA repair toolkit to chart cancer evolution

The ongoing fight of science against cancer has made great strides, but cancer cells have not made it easy. The complexity of cancer cells and their adaptive evolutionary nature complicate the search for effective cures. ...

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Nucleotide

Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling (cGMP and cAMP), and are incorporated into important cofactors of enzymatic reactions (coenzyme A, FAD, FMN, and NADP+). Nucleotide derivatives such as the nucleoside triphosphates play central roles in metabolism, in which capacity they serve as sources of chemical energy (ATP and GTP).

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