Autism spectrum disorders

High levels of estrogen in the womb linked to autism

Scientist have identified a link between exposure to high levels of oestrogen sex hormones in the womb and the likelihood of developing autism. The findings are published today in the journal Molecular Psychiatry.

Diseases, Conditions, Syndromes

Oestrogen levels linked to risk of COVID-19 death in older women

An older woman's oestrogen levels may be linked to her chances of dying from COVID-19, with higher levels of the hormone seemingly protective against severe infection, suggests research published in the open access journal ...

Oncology & Cancer

Discovery opens door for breast, prostate cancer treatments

(Medical Xpress)—A team of Western Australian cancer researchers interested in the strong link between hormones and cancer have discovered three new molecules that may have an important role to play in future breast and ...

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Estrogen

Estrogens (AmE), oestrogens (BE), or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal. Their name comes from the Greek words estrus/οίστρος = sexual desire + gen/γόνο = to generate.

Estrogens are synthesized in all vertebrates as well as some insects. Their presence in both vertebrates and insects suggests that estrogenic sex hormones have an ancient evolutionary history.

Estrogens are used as part of some oral contraceptives, in estrogen replacement therapy for postmenopausal women, and in hormone replacement therapy for trans women.

Like all steroid hormones, estrogens readily diffuse across the cell membrane. Once inside the cell, they bind to and activate estrogen receptors which in turn modulate the expression of many genes. Additionally, estrogens have been shown to activate a G protein-coupled receptor, GPR30.

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