(Medical Xpress)—Researchers from the US and Japan have shown that an aggressive type of brain tumor can arise from normal cells in the central nervous system such as neurons. The cells revert to an earlier, undifferentiated ...
In the late 1970s, the relationship between the c-Src gene and cancer was discovered. The first oncogene was identified. Since then, c-Src has been found to be overactivated in half of colon, liver, lung, breast, prostate ...
Oct 31, 2023
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A gene that University of Virginia (UVA) Health researchers have discovered is responsible for the deadliest type of brain tumor is also responsible for two forms of childhood cancer, the scientists have found.
Jul 28, 2022
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One of the major successes of decades of cancer research has been the development of drugs that specifically inactivate oncogenes, genes that function abnormally, causing cells to behave erratically, become malignant and ...
Mar 1, 2022
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Cancer is a difficult disease to treat and to study, and can be caused by a range of genetic mutations. For instance, the mutated RAS gene causes a loss of structure in so-called epithelial tissue, a tissue type that lines ...
Nov 9, 2021
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Northwestern Medicine investigators have discovered the epigenetic mechanisms involved in the regulation of multiple oncogenes in glioma cells, mechanisms that promote overall glioma tumor growth and resistance to therapy, ...
Aug 26, 2021
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A research group at the RIKEN Center for Biosystems Dynamics Research (BDR) has discovered molecular events that determine whether cancer cells live or die. With this knowledge, they found that reduced consumption of a specific ...
Apr 27, 2021
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Scientists have identified an oncogene (a cancer-causing gene) responsible for glioblastoma, the deadliest brain tumor. The discovery offers a promising new treatment target for a cancer that is always fatal.
Jul 14, 2020
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Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the ...
Sep 23, 2019
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The Fast and the Furious movie franchise meets the Fast N' Loud television series to define an oncogene that drives 35% of prostate cancers.
Jun 26, 2019
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An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a cancer cell.
Many cells normally undergo a programmed form of death (apoptosis). Activated oncogenes can cause those cells to survive and proliferate instead. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors, such as viral infection, to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target those DNA sequences and their products.
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