A research team led by Hong Kong Baptist University (HKBU) has identified a molecular target for bone anabolic therapies using a selected aptamer that serves as an inhibitor of sclerostin, a protein that prevents bone growth. ...
Dec 19, 2022
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The building blocks of a structure consist of load-bearing elements that rarely change despite renovations or repairs. They remain intact and consistent over time, but in the human body, our building blocks do just the opposite.
Sep 12, 2022
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A new study led by Baylor College of Medicine identifies an underlying mechanism of pathogenesis for osteogenesis imperfecta (OI) in human bone. The report, published in the Journal of Clinical Investigation, also shows the ...
Feb 16, 2022
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Osteogenesis imperfecta (OI) is the most common genetic form of brittle bone disease and results in defects of both bone and connective tissue. OI patients can have significant problems with mobility due to joint dysfunction ...
Jun 14, 2021
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A multidisciplinary team headed by Valencia University (UV) professor Juan Alberto Sanchis Gimeno reports on the link between the shape of the ribs and lung function in patients with osteogenesis imperfecta, a rare disease ...
Feb 17, 2020
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Osteogenesis imperfecta, also known as brittle bone disease, is a genetic disorder that causes bones to break easily. Severe cases of the disease can result in hundreds of fractures during a person's lifetime or even death. ...
Jan 30, 2017
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Previous case reports in patients with osteogenesis imperfecta (OI) have suggested that treatment with bisphosphonates, which are commonly prescribed for osteoporosis, may be associated with atypical femur fractures. A new ...
Jan 9, 2017
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An international team of researchers has discovered the mutation responsible for a rare, newly identified genetic disorder that causes craniofacial abnormalities and developmental delays. The mutation disrupts normal protein ...
Jul 28, 2016
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(HealthDay)—In children with type 3 osteogenesis imperfecta (OI) and thoracic insufficiency syndrome (TIS), thoracic elongation surgery using a novel expandable spino-thoracic fixation device significantly improves pulmonary ...
Nov 20, 2012
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