Medications
Tapeworm drug targets common vulnerability in tumor cells
A drug used to treat tapeworm infections could also be used to fight a wide range of cancers, an A*STAR study suggests.
Mar 18, 2019
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News tagged with p53 function
Oncology & Cancer
Team finds mitochondrial stress induces cancer-related metabolic shifts
Cancerous tumors must be fed. Their unregulated growth requires a steady stream of blood flow and nutrients. Thus, one way that researchers have tried to wipe out cancer is to target cells undergoing the metabolic shifts ...
Jul 6, 2016
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Oncology & Cancer
Drug kills cancer cells by restoring faulty tumor suppressor
A new study describes a compound that selectively kills cancer cells by restoring the structure and function of one of the most commonly mutated proteins in human cancer, the "tumor suppressor" p53. The research, published ...
May 14, 2012
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Oncology & Cancer
Tumor-suppressor p53 regulates protein that stifles immune attack on cancer
A crucial tumor-thwarting gene protects an immune attack against lung cancer by blocking the key to an off switch on T cells, the customized warriors of the immune system, a team led by researchers at The University of Texas ...
Nov 20, 2015
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Medical research
Aurka-to-p53 signaling: A link between stem cell regulation and cancer
Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role for an oncogenic signaling pathway in embryonic stem cell (ESC) self-renewal and in reprogramming ...
Aug 3, 2012
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Diseases, Conditions, Syndromes
Explaining heart failure as a cause of diabetes
Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers reporting in the January Cell Metabolism appear to have found the culprit that leads from heart ...
Jan 3, 2012
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Medical research
Study discovers that stem cell senescence drives aging
Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor ...
Apr 18, 2013
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Medical research
Complex interactions between proteins Rbm38 and p53 govern tumor suppression, aging
Scientists have long known the p53 protein suppresses tumors. However, a recent animal study by UC Davis researchers has uncovered a complicated relationship between p53 and another protein, Rbm38, highlighting how the body ...
Dec 15, 2014
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Immunology
Scientists find promising way to boost body's immune surveillance via p53
Researchers at A*STAR's Singapore Immunology Network (SIgN) have discovered a new mechanism involving p53, the famous tumour suppressor, to fight against aggressive cancers. This strategy works by sabotaging the ability of ...
Sep 18, 2013
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Oncology & Cancer
New study reveals how tumor suppressor p53 shut down in metastatic melanoma
Cancer cells are a problem for the body because they multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don't belong. One protein that keeps healthy cells from behaving this way ...
Apr 25, 2013
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