Neuroscience

Mind over matter: Amygdala circuit counteracts pain-driven emotion

Two pathways in the brain converging at the amygdala regulate the anxiety and depression that often accompanies chronic pain, suggests research in male rats published in JNeurosci. One of these pathways may represent a top-down ...

Neuroscience

Molecule may be key to pain relief in diabetic neuropathy

A new study published in the Journal of Clinical Investigation has identified a key molecule that contributes to painful diabetic neuropathy, an incurable nerve disease that affects about one-quarter of all patients with ...

Medications

Scientist searches for alternatives to opioids

Since ancient times, humans have used opium and its derivatives to block pain. Yet in all that time, no one has found a solution to two main side effects of opioids—addiction and overdose.

Neuroscience

Why head and face pain causes more suffering

Hate headaches? The distress you feel is not all in your—well, head. People consistently rate pain of the head, face, eyeballs, ears and teeth as more disruptive, and more emotionally draining, than pain elsewhere in the ...

Diseases, Conditions, Syndromes

Study a breakthrough in understanding chronic pain in children

A University of Calgary psychologist who studies pediatric pain has made a breakthrough in understanding the cause of chronic pain in adolescents—by focusing on those recovering from major surgeries.

Medications

Chronic pain patients say opioid crackdown is hurting them

Jim Watkins lives with pain so intense it can snatch his breath away. He has osteogenesis imperfecta, also known as brittle bone disease, and the best way he has found to control the anguish is with daily doses of tramadol, ...

Medications

Overcoming Opioids: The quest for less addictive drugs

Tummy tucks really hurt. Doctors carve from hip to hip, slicing off skin, tightening muscles, tugging at innards. Patients often need strong painkillers for days or even weeks, but Mary Hernandez went home on just over-the-counter ...

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