With nearly 10% of the world's population affected, type 2 diabetes is a major public health issue. An excessively sedentary lifestyle and excessively caloric diet encourage the development of this metabolic disease by altering ...
Jan 12, 2022
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Microtubules—cellular "highways" that deliver cargo to the cell membrane for secretion—have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team ...
Dec 4, 2015
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A new study helps to explain the mechanism by which pancreatic cells secrete high levels of insulin during the early stages of diabetes.
Dec 20, 2019
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Researchers have discovered that adipsin, a cell signaling protein made by fat cells, plays a critical, previously unsuspected role in stimulating insulin secretion to control blood sugar, according to a report from Dana-Farber ...
Jul 4, 2014
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A cellular defect that can impair the body's ability to handle high glucose levels and could point the way to a potential new treatment for diabetes has been identified by Columbia University Medical Center (CUMC) researchers. ...
Apr 7, 2015
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Research led by a Johns Hopkins University biologist demonstrates the workings of a biochemical pathway that helps control glucose in the bloodstream, a development that could potentially lead to treatments for diabetes.
Nov 14, 2016
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(Medical Xpress)—Working with mice and human blood and liver samples, scientists from the Johns Hopkins Children's Center have identified a previously unsuspected liver hormone as a critical player in the development of ...
Apr 3, 2014
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Insulin is a vital hormone produced by pancreatic beta cells. Type 1 diabetes is caused by the destruction of these cells, which results in patients having to replace the lost insulin with multiple daily injections.
Mar 3, 2022
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Movement of secretory molecules, such as hormones and digestive enzymes, out of the cell is known as exocytosis. This process is guided by SNARE proteins, which help the fusion of secretory vesicles with the plasma membrane. ...
Dec 8, 2016
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Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop drugs for boosting insulin production in people with Type 2 ...
Nov 13, 2020
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