A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study ...
Nov 9, 2023
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Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. ...
Jul 5, 2023
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Scientists at the University of Augsburg and Helmholtz Munich have made an important breakthrough in better understanding early processes in the development of type 2 diabetes by identifying a previously unknown transmission ...
Feb 13, 2023
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Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop drugs for boosting insulin production in people with Type 2 ...
Nov 13, 2020
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A new study helps to explain the mechanism by which pancreatic cells secrete high levels of insulin during the early stages of diabetes.
Dec 20, 2019
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Research led by a Johns Hopkins University biologist demonstrates the workings of a biochemical pathway that helps control glucose in the bloodstream, a development that could potentially lead to treatments for diabetes.
Nov 14, 2016
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New research shows that a cellular program that causes aging can also bring unexpected benefits in the function of pancreatic beta cells and the production of insulin in mice and humans. The findings are reported in the journal ...
Mar 7, 2016
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Microtubules—cellular "highways" that deliver cargo to the cell membrane for secretion—have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team ...
Dec 4, 2015
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A team led by researchers from the Perelman School of Medicine at the University of Pennsylvania found that a susceptibility gene for type 1 diabetes regulates self-destruction of the cell's energy factory. They report their ...
Jun 19, 2014
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(Medical Xpress)—Working with mice and human blood and liver samples, scientists from the Johns Hopkins Children's Center have identified a previously unsuspected liver hormone as a critical player in the development of ...
Apr 3, 2014
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