Immunology

Cell senescence is regulated by innate DNA sensing

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due ...

Immunology

Study shows immune cells have a backup mechanism

The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral ...

Neuroscience

Why is the brain so prone to inflammation?

All living cells teem with ribonucleic acid (RNA), molecules that relay genetic messages to keep cells functioning. But these necessary molecules can also set off cellular alarms. The long twisted-together strands of RNA ...