Oncology & Cancer

Scientists identify new target for wide array of cancers

Many types of human cancers exhibit changes in kinase and phosphatase balances. Drugs that inhibit kinase activity have shown success in the clinic as cancer therapeutics, but the phosphatases still remain a largely underexploited ...

Genetics

Discovery shows promise for treating Huntington's disease

Huntington's disease is a progressive and aggressively debilitating brain disorder that causes uncontrolled movements, psychological problems, and loss of cognition. It is caused by a mutation in the gene that encodes the ...

Oncology & Cancer

Mystery about the cancer drug nelarabine solved after decades

Acute lymphoblastic leukemia (ALL) is the most common kind of cancer in children. T-ALL, a subtype that resembles T-lymphocytes, can be treated successfully with the drug nelarabine. The drug has not been successful, however, ...

Psychology & Psychiatry

SHANK3: the good, the bad and the hopeful

Some neuropsychiatric conditions may boil down to how well brain cells communicate with each other. This can be affected by a number of factors, including having too much or too little of proteins that function at the synapse—the ...

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