Scientists report in a new study that by imitating a natural process of cells, they prevented the formation of protein clumps associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
Aug 8, 2017
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A good night's sleep can work wonders for both mind and body. But what is it that determines how much we need to sleep, and what can cause us to sleep more deeply?
Dec 8, 2022
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Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the ...
Jun 11, 2019
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In a new study by Sanford Burnham Prebys Medical Discovery Institute (SBP), researchers have identified a novel kinase cascade that regulates mTORC1, a protein complex implicated in the control of cancer cell growth in response ...
Aug 14, 2015
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A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism. The findings, ...
Mar 8, 2013
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Worldwide, cancer is the second leading cause of death—in 2018 alone, it claimed approximately 9.6 million lives, or one in six deaths. The development of cancer is incredibly complex and is controlled by an interplay of ...
Sep 11, 2020
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A functional biomarker that can predict whether BRAF-mutant melanomas respond to drugs targeting BRAF could help guide the treatment of patients with these cancers, according to results presented here at the AACR-NCI-EORTC ...
Oct 22, 2013
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UC Irvine scientists studying the role of circadian rhythms in skin stem cells found that this clock plays a key role in coordinating daily metabolic cycles and cell division.
Jan 6, 2015
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Researchers have discovered that a protein called phosphorylated α-synuclein, which is associated with several neurodegenerative diseases such as Parkinson's disease and Lewy body dementia, is also involved in the normal ...
Jan 9, 2024
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(HealthDay)—Smoking-induced insulin resistance, which improves with smoking cessation, may be due to activation of mammalian target of rapamycin (mTOR), according to a study published online Sept. 10 in Diabetes.
Sep 17, 2012
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