Medical research

New therapeutic approaches for SARS-CoV-2

Medicine has two things to offer when viral pandemics hit: vaccines and therapeutics. While it is hard to undervalue the noble goal of rapidly developing and rolling out safe vaccines that effectively reduce disease severity, ...

Diseases, Conditions, Syndromes

Uracil switch in SARS-CoV-2 genome alters innate immune responses

Tohoku University scientists have found that human editing enzymes are likely behind a type of mutation in the COVID-19 virus that stimulates the release of pro-inflammatory molecules called cytokines by immune cells in the ...

Genetics

Artificial RNA editing with ADAR for gene therapy

Many of the diseases caused by point mutations have no established therapeutic approaches. Prof. Tsukahara and colleagues (Japan Advanced Institute of Science and Technology) are studying a therapeutic method using artificial ...

Neuroscience

How nerves may lose their insulation

Charcot-Marie-Tooth (CMT) disease is the most common inherited disorder of the peripheral nerves in humans, affecting 1 in every 2,500 people. There is no cure for the disease, which causes severe disability due to disruptions ...

Oncology & Cancer

No tumor is an island

For decades tumors have been viewed as 'other'—malignant, unruly growths that are distinctly separate from the ordered physiological system within which they live. This view has shaped our approach to treat cancer: cut ...

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