Diseases, Conditions, Syndromes

New skin test detects prion infection before symptoms appear

Prions can infect both humans and animals, causing Creutzfeldt-Jakob disease (CJD) in humans, mad cow disease in cattle, and chronic wasting disease in elk and deer. The infectious, misfolded protein particles often go undetected ...

Alzheimer's disease & dementia

Test detects protein associated with Alzheimer's and CTE

An ultrasensitive test has been developed that detects a corrupted protein associated with Alzheimer's disease and chronic traumatic encephalopathy (CTE), a condition found in athletes, military veterans, and others with ...

Neuroscience

How prions invade the brain

The spread of prions to the brain does not occur by direct transmission across the blood-brain barrier, according to a study published November 29 in the open-access journal PLOS Pathogens by Annika Keller and Adriano Aguzzi ...

Diseases, Conditions, Syndromes

Not all prion strains interfere with each other

The first example of prion strains that replicate independently in vitro and in vivo suggests that strain diversity may be greater than previously thought, according to a study published October 18 in the open-access journal ...

Neuroscience

Researchers create first artificial human prion

Case Western Reserve University School of Medicine researchers have synthesized the first artificial human prion, a dramatic development in efforts to combat a devastating form of brain disease that has so far eluded treatment ...

Diseases, Conditions, Syndromes

Microglia are key defenders against prion diseases

Prion diseases are slow degenerative brain diseases that occur in people and various other mammals. No vaccines or treatments are available, and these diseases are almost always fatal. Scientists have found little evidence ...

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