Many changes take place in the brain long before symptoms appear. This has been shown in mice in two studies of prion diseases in which the brain gradually deteriorates. The results suggest that changes can be studied extremely ...
Oct 10, 2022
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Approximately two years after establishing a human cerebral organoid system to study Creutzfeldt-Jakob disease (CJD), National Institutes of Health researchers have further developed the model to screen drugs for potential ...
Mar 9, 2021
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Human prion diseases include Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSS). A new study in the open-access journal PLOS Biology reports a significant advance in the development of mouse ...
Jun 9, 2020
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Infectious proteins called prions cause a group of related, fatal and incurable neurodegenerative disorders, including bovine spongiform encephalopathy or Mad Cow disease and Creutzfeldt-Jakob disease, both of which affect ...
Jun 11, 2019
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(HealthDay)—Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) has high diagnostic specificity and sensitivity for prion diseases, according to a study published online Nov. 28 in the Annals of Neurology.
Dec 3, 2016
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When prion proteins mutate, they trigger mad cow and Creutzfeldt-Jakob disease. Although they are found in virtually every organism, the function of these proteins remained unclear. Researchers from the University of Zurich ...
Aug 8, 2016
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(Medical Xpress)—A team of researchers with the UCL Institute of Neurology in the U.K. with assistance from a pair of researchers in New Guinea, has found a gene mutation that confers complete resistance against a type ...
By directly manipulating a portion of the prion protein-coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans. The highly accurate reproduction of ...
Aug 19, 2013
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Unlocking the mechanisms that cause neurodegenerative prion diseases may require a genetic key, suggest new findings reported by University of Illinois at Chicago distinguished professor of biological sciences Susan Liebman.
May 26, 2011
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