Cardiology

Doxorubicin disrupts the immune system to cause heart toxicity

Doxorubicin is a chemotherapy drug widely used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart ...

Cancer

Biologists studied cellular cannibalism in cancerous growths

Researchers from Lomonosov MSU Faculty of Biology have studied the stages of entosis, a process of cell death when one cell invades the other and is digested inside of it. Entosis could become a new method of destroying cancer ...

Immunology

New treatment approach for autoimmune disorder

Researchers from Charité—Universitätsmedizin Berlin have been able to improve their understanding of the key mechanism involved in the pathogenesis of a serious autoimmune disease. For the first time, researchers were ...

Cancer

Overall survival up for melanoma brain metastases

(HealthDay)—Overall survival (OS) for patients with melanoma brain metastases (MBM) has improved significantly since 2000, according to a study published online Oct. 12 in Cancer.

Cancer

Checkpoint inhibitors no less safe with radiation

(HealthDay)—Immune-related adverse events (IRAEs), including pneumonitis, are not more common in patients with metastatic lung cancer who receive both immune checkpoint inhibitors (CPIs) and thoracic radiotherapy (TRT), ...

Cancer

Immune checkpoint inhibitor endocrine dysfunction explored

(HealthDay)—Patients receiving immune checkpoint inhibitor (ICI) regimens may experience endocrine dysfunction, with increased risk of thyroid dysfunction and hypophysitis for patients on combination therapy, according ...

Cancer

Alternative splicing, an important mechanism for cancer

Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death. Thanks to the advances ...

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Programmed cell death

Programmed cell-death (or PCD) is death of a cell in any form, mediated by an intracellular program. In contrast to necrosis, which is a form of cell-death that results from acute tissue injury and provokes an inflammatory response, PCD is carried out in a regulated process which generally confers advantage during an organism's life-cycle. PCD serves fundamental functions during both plant and metazoa (multicellular animals) tissue development.

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