Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF), identified a common mechanism in two forms of neurodegeneration that affect young adults or the elderly. The discovery advances ...
Apr 12, 2017
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Researchers at the University of Kentucky's College of Medicine have found that a class of antibiotics called aminoglycosides could be a promising treatment for frontotemporal dementia.
Jan 10, 2020
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Dementia encompasses a range of neurodegenerative conditions that lead to memory loss and cognitive deficiencies and affect some 55 million people worldwide. Yet despite its prevalence, there are few effective treatments, ...
Oct 27, 2022
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Scientists from the Gladstone Institutes identified that mutations in a protein commonly linked to frontotemporal dementia (FTD) result in obsessive-like behaviors. They linked these behaviors to immune pathways, implicating ...
Apr 24, 2017
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Scientists from Japan have identified a molecule that aids a crucial "pruning" process in the brain that, if malfunctioning, could lead to disorders such as autism and dementia.
Feb 1, 2018
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In a recent study in Human Molecular Genetics, researchers from VIB and KU Leuven led by prof. Philip Van Damme, reveal a novel function for progranulin in lysosomes: it acts as chaperone of the lysosomal protease cathepsin ...
May 8, 2017
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Progranulin is produced and secreted by most cells in the body. From skin to immune cells, brain to bone marrow cells, progranulin plays a key role in maintaining normal cellular function. In cancer, too much progranulin ...
Nov 30, 2016
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A recent review paper published in the journal Cancers highlights the important role of the growth factor progranulin in the initiation and progression of cancer.
Mar 31, 2023
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