Alexander disease is a progressive and rare neurological disorder with no cure or standard course of treatment. But a new study led by researchers at the University of Wisconsin–Madison involving a rat model of the disease ...
Nov 17, 2021
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The older we grow, the weaker our muscles get, riddling old age with frailty and physical disability. But this doesn't only affect the individual, it also creates a significant burden on public healthcare. And yet, research ...
Jan 19, 2021
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Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain. Researchers including Mathias Jucker ...
Nov 17, 2020
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In many neurodegenerative diseases like Parkinson's, protein aggregates form in the brain and are assumed to contribute to neuronal cell death. Yet there exists a cellular defense mechanism that counteracts these aggregates, ...
Nov 11, 2020
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A master control region of a protein linked to Parkinson's disease has been identified for the first time.
Mar 9, 2020
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108
West Nile virus (WNV) inhibits autophagy to induce the aggregation of proteins in infected cells, triggering cell death and brain inflammation (encephalitis), according to Hokkaido University researchers. They also discovered ...
Jan 23, 2020
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Protein aggregation—in which misfolded proteins clump together to form large fibrils—has been implicated in many diseases including Alzheimer's, Parkinson's, and type II diabetes. While the exact role these fibrils play ...
Aug 16, 2019
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ETH researchers have discovered a new mechanism that brain cells use to protect themselves from protein aggregates. Such aggregates play a key role in Parkinson's and other neurodegenerative diseases. This new finding might ...
Jun 6, 2019
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Alzheimer's-affected brains are riddled with amyloid plaques, protein aggregates consisting mainly of amyloid-β. However, amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic ...
Jan 11, 2019
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Alzheimer's disease (AD) is the most common form of dementia, involving memory loss and a reduction in cognitive abilities. Patients with AD develop multiple abnormal protein structures in their brains that are thought to ...
Oct 15, 2018
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