Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of malignant tumors. However, ...
May 4, 2021
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Scientists are still a long way from being able to treat Alzheimer's Disease, in part because the protein aggregates that can become brain plaques, a hallmark of the disease, are hard to study. The plaques are caused by the ...
Feb 26, 2021
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Alzheimer's disease is the leading cause of dementia worldwide and a major cause of disability. Now, researchers at Osaka University and Hokkaido University have shown that repeated precipitation-dissolution events of salt ...
Jul 27, 2020
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Utrecht scientists have uncovered how aggregates alter the behavior of Tau protein, known to play a role in Alzheimer's disease. On a molecular level, the researchers have revealed why certain proteins tend to bind to Tau ...
Jan 31, 2020
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Neurodegenerative diseases such as Alzheimer's and Parkinson's can be devastating to patients and their families. These diseases are difficult to diagnose before symptoms show, meaning it's often already too late to reverse ...
Dec 17, 2019
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Protein aggregates have been observed in the nerve tissue of patients with Parkinson's disease which consist of individual components (monomers) of the protein α-synuclein which assemble into what are referred to as amyloid ...
Sep 3, 2019
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Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer's patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier—the normally tight border that ...
Aug 12, 2019
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The true cause of Parkinson's disease is still a mystery to researchers, although they do know that in many patients, a protein called alpha-synuclein (aSyn) tends to aggregate in brain cells. But a different protein could ...
Jun 11, 2019
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Brazilian scientists identify the predominant presence of a truncated variant of the p53 protein in amyloid aggregates in endometrial cancer cells. Such structures are related to the progression of this tumor.
May 6, 2019
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New research reveals RNAs, which are crucial for cells to produce proteins, are also involved in protein aggregation, where proteins do not fold properly and 'clump' together into aggregates. If cells cannot clear these away, ...
Feb 8, 2019
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