Oncology & Cancer

Brain cancer linked to nuclear pore alterations

Several types of cancer are believed to be linked to alterations of macromolecular structures known as nuclear pore complexes (NPCs). These structures are embedded in the nuclear envelope, a membrane barrier that separates ...

Oncology & Cancer

First-in-class targeted microRNA therapy slows cancer tumor growth

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division. As reported in Oncogene, tumors treated with the ...

Endocrinology & Metabolism

Metabolism meets signaling to fine-tune cell growth

Cells use a variety of metabolic pathways to synthesize the building blocks for growth and proliferation. To ensure balanced growth, these biosynthetic processes must be tightly coordinated. Researchers from the Max Planck ...

Immunology

How dendritic cells activate the immune system

The specific or acquired immune system of vertebrates is a powerful weapon against pathogens and pathologically altered body cells. Here, T cells play a special role. After activation, they can systematically kill off target ...

Immunology

Mapping the development of infection-fighting immune cells

The immune system protects the body from invaders, such as bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs. Specialized immune cells, called cytotoxic T cells, can develop into short-lived ...

Oncology & Cancer

Putting the STING into cancer immunotherapy

Immune checkpoint blockade therapies have been revolutionary in the treatment of some cancer types, emerging as one of the most promising treatments for diseases such as melanoma, colon cancer and non-small cell lung cancer.

Medications

Study reveals epigenetic vulnerability of acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive blood cancer that causes uncontrolled accumulation of white blood cells. Because of the poor outcomes of this disease, researchers across the globe have been on the hunt for new ...

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