Genetics

Killer T vs. memory: DNA isn't destiny for T cells

Scientists at St. Jude Children's Research Hospital have solved an immunology puzzle. A CD8+ T cell can have two functionally distinct daughter cells after it divides, despite the cells being genetically identical. The researchers ...

Immunology

Mitochondrial respiratory chain sustains inflammation

Northwestern Medicine investigators recently discovered that the mitochondrial respiratory chain—a series of protein complexes essential for a cellular respiration and energy production—is necessary for the activation ...

Oncology & Cancer

New gene targets for treating adult blood cancer

Hokkaido University scientists have identified new targets for treating an aggressive form of adult leukemia with existing drugs. The findings were published in the journal Blood.

Medications

How a widely used diabetes medication actually works

Physicians have used the drug metformin to treat type 2 diabetes for more than half a century, but despite its prevalence, researchers have lacked a clear understanding of how it works. Now, Yale researchers have elucidated ...

Medical research

Looking beyond DNA to see cancer with new clarity

Researchers at UC San Francisco and UC San Diego have mapped out how hundreds of mutations involved in two types of cancer affect the activity of proteins that are the ultimate actors behind the disease. The work points the ...

Oncology & Cancer

Investigators uncover cellular pathway involved in cancer growth

The Cedars-Sinai investigators discovered several key components in the control of telomerase reverse transcriptase, or TERT, expression, one of the necessary component proteins of telomerase. High levels of TERT are found ...

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