Medical research

Novel paradigm in drug development

Traditional medicines mostly function as inhibitors, attacking the disease-relevant proteins that cause cancer, by binding to their accessible pockets. Following this strategy, only ~20% of all proteins are chemically addressable, ...

Medical research

Identification of autophagy-dependent secretion machinery

A group of researchers identified a molecular machinery by which autophagy mediates secretion. These results underscore an important role of autophagy other than degradation, and will bring us to future translational research ...

Medical research

Targeting cancer proteins for degradation

Cancer research is increasingly focusing on therapeutic approaches in which disease causing proteins are marked for early degradation. Nicolas Thomä and his group at the Friedrich Miescher Institute for Biomedical Research ...

Cardiology

Slowing down muscle loss in heart failure patients

Patients in advanced states of myocardial insufficiency generally lose their muscle mass and muscle strength. Indeed, that fact has, until now, negatively impacted the clinical course of the disease and has resulted in poor ...

Medical research

Researchers identify novel factor involved in autophagy

Neurodegenerative disorders such as Alzheimer's disease are typically characterized by protein deposits in the brain. These are comprised of defective, insoluble proteins which no longer fulfill their function and which cells ...

Medical research

Insights into a rare genetic disease

Recently, a grassroots effort initiated by families and clinicians led to the discovery of a human genetic disorder with severe consequences that is linked to a mutation in the human NGLY1 gene. In a big step towards understanding ...

Medical research

Mechanism of action of thalidomide elucidated

(Medical Xpress)—Scientists led by Nicolas Thomä at the Friedrich Miescher Institute for Biomedical Research have clarified the workings of thalidomide at the molecular level. Their analysis of various structures, published ...

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