Last month, the U.S. Food and Drug Administration (FDA) approved the use of the drug capivasertib, in combination with a current cancer treatment called fulvestrant for patients with the most common type of breast cancer, ...
Dec 21, 2023
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A "chaperone" molecule that slows the formation of certain proteins reversed disease signs, including memory impairment, in a mouse model of Alzheimer's disease, according to a study from researchers at the Perelman School ...
Dec 20, 2023
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Researchers at the Center for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS. These are ...
Dec 18, 2023
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In a novel study, researchers from the Icahn School of Medicine at Mount Sinai have introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain and loss-of-function variants across the genome.
Dec 14, 2023
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Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death. A study led by the Protein Kinases ...
Dec 14, 2023
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A team of researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS), Sun Yat-Sen University, and Stanford University, has revealed a comprehensive molecular atlas of the ...
Nov 30, 2023
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A review paper titled "Targeting Ras with protein engineering" has been published in Oncotarget.
Nov 27, 2023
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UCLA researchers have described a previously unknown step in the complex process by which dietary cholesterol is processed in the intestines before being released into the bloodstream—potentially revealing a new pathway ...
Nov 9, 2023
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An experimental drug can reduce the toxic changes in tau proteins known to damage neurons in brains with Alzheimer's disease, researchers from Yale School of Medicine and Johns Hopkins University report.
Nov 6, 2023
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Targeted cancer drugs are widely used because of their ability to inhibit specific proteins involved in cancer development with fewer side effects compared to chemotherapy drugs. But targeted therapies can often inhibit other ...
Oct 16, 2023
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