When Dr. Stephen Smith of Seattle Children's Research Institute came down with muscle aches, gastrointestinal distress and a sudden loss of smell in late February, he suspected he had COVID-19. The testing criteria had yet ...
Oct 23, 2020
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116
UNC-Chapel Hill researchers have, for the first time, determined the high-resolution structure of a key DNA-sensing protein in the innate immune system called cGAS while it is bound to the nucleosome—the all-important unit ...
Sep 10, 2020
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93
A Rutgers-led team may have found the key to treating inflammatory diseases like asthma, allergies, chronic fibrosis and chronic obstructive pulmonary disease (COPD).
Aug 17, 2020
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87
As the novel coronavirus spreads, it's picking up new mutations—for better and for worse.
Aug 13, 2020
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89
As many as 90 percent of promising drug candidates fail before or during human clinical trials, falling into the so-called "valley of death."
Mar 16, 2020
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105
Autism can bestow brilliance as well as cognitive difficulty, but how either scenario plays out in the brain is not clear. Now a study by University of Toronto researchers has found that a tiny gene fragment impacts the brain ...
Jan 29, 2020
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690
A novel anticancer molecule created by researchers at The Wistar Institute showed therapeutic activity in preclinical models of various cancer types. This cell-permeable peptidomimetic was designed to disrupt a newly identified ...
Oct 3, 2019
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5
The chemical interactions that give proteins their shape may be weaker and more numerous than previously recognized. These weak connections provide a new way for researchers to understand proteins that cause disease and help ...
Jul 24, 2019
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193
A de novo gene mutation that encodes a brain protein in a child with autism has been placed into the brains of mice. These mice then showed severe alterations of specific behaviors that closely resemble those seen in human ...
Jul 24, 2019
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206
Among the confounding challenges of diagnosing and treating Alzheimer's disease (AD) is the fact that patients with asymptomatic and symptomatic versions of the degenerative condition may share similar neuropathological burdens ...
Jul 24, 2019
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