Neuroscience

Balancing mitochondrial dynamics in Alzheimer's disease

(Medical Xpress)—Many diseases are multifactorial and can not be understood by simple molecular associations alone. Alzheimer's disease (AD)is associated with toxic transformations in two classes of protein,amyloid beta ...

Neuroscience

Controlling mood through the motions of mitochondria

(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined into narrow neuritic ...

Medications

Repurposed cancer treatments could be potential Alzheimer's drugs

Existing and emerging cancer drugs could be repurposed as therapies to be tested in clinical trials for people at genetic risk of Alzheimer's disease, according to a new study published in Science Advances. Research combining ...

Medical research

Sleep and synaptic rhythms

Chronobiologists at Ludwig-Maximilians-Universität (LMU) in Munich, Germany, show in two articles in the journal Science how critical the sleep-wake cycle is for protein and phosphorylation dynamics in synapses to ultimately ...

Neuroscience

Reversible changes to neural proteins may explain sleep need

Long periods of waking can lead to cognitive impairment, and the need to sleep continues to build up. Sleep then refreshes the brain through alterations in molecular biochemistry. These changes impact neuronal plasticity ...

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