Northwestern Medicine investigators have discovered the mechanisms by which a particular protein promotes cancer cell proliferation and survival in acute myeloid leukemia (AML), according to a Northwestern Medicine study ...
Nov 4, 2022
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In recent years, much scientific effort and funding has focused on developing drugs that target an enzyme with the unwieldy name of Src homology 2-containing protein tyrosine phosphatase 2 or more briefly, Shp2.
Nov 9, 2021
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A team of researchers led by biomedical scientist Declan F. McCole at the University of California, Riverside, has found that the drug tofacitinib, also called Xeljanz and approved by the FDA to treat rheumatoid arthritis ...
Sep 30, 2020
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A team with members affiliated with several institutions in the U.S. has found that disabling the gene responsible for the production of the protein tyrosine phosphatase D (PTPRD) caused test mice to self-administer less ...
Diabetes has become a major health problem worldwide; some estimates suggest that in 20 years, there will be around 600 million diabetics. The disease is caused by impaired insulin secretion, which in turn hinders cell glucose ...
Feb 8, 2018
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Remyelination is a critical repair process in demyelinating diseases such as multiple sclerosis (MS). Chondroitin sulfate proteoglycans (CSPGs), a family of large molecules consisting of a core protein and glycosaminoglycans ...
Dec 8, 2017
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Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type ...
Nov 28, 2017
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A protein found in the cells lining blood vessels plays a central role in preventing fluid and inflammatory cells from leaking into lung tissue in a low-oxygen environment, Weill Cornell Medicine researchers discovered.
Jul 18, 2017
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Investigators at Rush University Medical Center and the Brigham and Women's Hospital in Boston reported the discovery of a new gene that is associated with susceptibility to a common form of brain pathology called Tau that ...
Mar 24, 2017
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In 2011, Igor Stagljar, a professor in the University of Toronto's Donnelly Centre, came across a study that genetically linked two genes in the cell to a hard-to-treat (triple negative) breast cancer. It was not clear how ...
Jan 5, 2017
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