Medical research

Mitochondrial mutations and disease

Mitochondria are cellular organelles with their own DNA. Their role in power generation makes them susceptible to oxidative damage, including the formation of DNA-damaging chemical complexes called adducts.

Oncology & Cancer

Lung cancer triggers pulmonary hypertension

Shortness of breath and respiratory distress often increase the suffering of advanced-stage lung cancer patients. These symptoms can be triggered by pulmonary hypertension, as scientists at the Max Planck Institute for Heart ...

Medical research

Targeting mitochondria in pulmonary hypertension

Pulmonary Arterial Hypertension (PAH) is a debilitating disease of the lung blood vessels that causes heart failure and early death, affecting hundreds of thousands of patients worldwide. Available therapies fail to prolong ...

Oncology & Cancer

Block estrogen to treat lung disease

The strongest epidemiological risk factor for many forms of pulmonary arterial hypertension (PAH) is female gender. Increased estrogen makes females three times more likely to develop PAH, a chronic disease that eventually ...

Cardiology

Breathing in a new gene therapy to treat pulmonary hypertension

Mount Sinai has partnered with Theragene Pharmaceuticals, Inc. to advance a novel airway-delivered gene therapy for treating pulmonary hypertension (PH), a form of high blood pressure in blood vessels in the lungs that is ...

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