Oncology & Cancer

YBX1 as a key regulator of mitochondrial pyruvate uptake

Cancer metastasis is a crucial area in cancer research that directly affects patient survival and treatment outcomes. Cancer cells often undergo adaptive metabolic changes during metastasis from in situ to distant organs ...

Neuroscience

Limiting energy in neurons exacerbates epilepsy

Epilepsy, one of the most common neurological disorders, is characterized by the spontaneous repetition of seizures caused by the hyperactivity of a group of neurons in the brain. Could we therefore reduce neuronal hyperactivity, ...

Biomedical technology

Sensor monitors disease severity by rapidly measuring lactate levels

Scientists have developed a prototype sensor that could help doctors rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples from patients, aiding in the rapid assessment of the severity of some diseases.

Diseases, Conditions, Syndromes

Supplement could protect against fetal Zika infection

The Zika virus shunts carbon atoms away from the important glucose metabolism pathway in infected fetuses, leading to a cascade of events that significantly impact fetal development. But giving pregnant mothers a readily ...

Oncology & Cancer

Possible key to beating colorectal cancer

Serine racemase (SRR) is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate. Though already well characterized, a team of researchers led ...

Oncology & Cancer

Magnetized molecules used to monitor breast cancer

A new type of scan that involves magnetising molecules allows doctors to see in real-time which regions of a breast tumour are active, according to research funded by Cancer Research UK and published in Proceedings of the ...

Oncology & Cancer

Breast cancer cells rely on pyruvate to expand in new tissues

Most patients who die of breast cancer die of metastasis, the process by which cancer cells spread to other organs of the body. Cancer cells alter their metabolism to grow and expand across other organs. A new study by Prof. ...

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