Immunology

Cells are able to 'talk to themselves' for better immune response

Research from the laboratories of Dr. André Veillette, Director of Research in Molecular Oncology at the Montreal Clinical Research Institute (IRCM) and Professor and Researcher in the Department of Medicine at the Université ...

Oncology & Cancer

Boosting the immune response against cancer

T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...

Genetics

Olfactory neurons adapt to the surrounding environment

Olfactory receptors, present on the surface of sensory neurons in the nasal cavity, recognize odorant molecules and relay this information to the brain. How do these neurons manage to detect a large variability of signals ...

Medical research

Protein linked to intellectual disability has complex role

Fragile X syndrome, the leading inherited cause of intellectual disability, is due to a genetic mutation that largely eliminates the fragile X protein, a critical element of normal brain development and function.

Neuroscience

Key protein identified for brain stem cell longevity

A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, ...

Neuroscience

Widespread brain receptor hides surprising mechanism of action

One of the most important molecules in the brain doesn't work quite the way scientists thought it did, according to new work by researchers at Columbia University Vagelos College of Physicians and Surgeons and Carnegie Mellon ...

Immunology

Double-stranded RNA induces bone loss during gum disease

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the ...

Diseases, Conditions, Syndromes

Evaluating an old molecule to fight SARS-CoV-2

In the spring of 2020, Université de Montréal biochemistry professor Christian Baron had an idea: Why not evaluate the inhibition capacity of a commercially available molecule called VE607 on the virus causing COVID-19?

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