In animals, a process of programmed cell death called apoptosis ensures cells die when they should. An opposing force, governed by inhibitor of apoptosis proteins (IAPs), guards against excessive cell death. Together these ...
Feb 9, 2023
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In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude ...
Feb 5, 2018
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(Medical Xpress) -- A team of Melbourne scientists has discovered a new type of cell in the immune system. Their findings could ultimately lead to the development of novel drugs that strengthen the immune response against ...
Jun 14, 2011
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Alzheimer's-affected brains are riddled with amyloid plaques, protein aggregates consisting mainly of amyloid-β. However, amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic ...
Jan 11, 2019
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A biochemical pathway long associated with diarrhea and intestinal function may provide a new therapeutic target for treating ADHD (Attention Deficit Hyperactivity Disorder) other neuropsychiatric disorders, according to ...
Aug 11, 2011
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At the molecular level, drugs like salvinorin A (the active ingredient of the hallucinogenic plant Salvia divinorum) work by activating specific proteins, known as receptors, in the brain and body. Salvinorin A, the most ...
Mar 21, 2012
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According to Gertrude Stein, "A rose is a rose is a rose," but new research indicates that might not be the case when it comes to the rose's scent. Researchers from the Monell Center and collaborating institutions have found ...
Dec 8, 2013
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Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the three-dimensional structure ...
Jan 17, 2018
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A team of neuroscientists at Georgetown University Medical Center has shown how a protein, known to accumulate in Parkinson's disease and other neurodegenerative diseases, activates the brain's immune response.
May 12, 2015
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For the first time, researchers have uncovered the significance of the molecular assembly processes—called biogenesis—of AMPA-type glutamate receptors for proper operation of the human brain. AMPA receptors, the most ...
Jul 7, 2017
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