Scientists at Johns Hopkins say they are one step closer to understanding the genetic mechanism of a rare, complex, multiple-gene disorder called Hirschsprung's disease. The results of their latest study suggest that many ...
Sep 30, 2016
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Whitehead Institute researchers have created a map of the DNA loops that comprise the three dimensional (3D) structure of the human genome and regulate gene expression in human embryonic stem (ES) cells and adult cells. The ...
Dec 10, 2015
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To mend a broken heart—that is, to regenerate a damaged cardiac muscle—it helps to know how hearts are built. "How does one stem cell, which has no specific identity, develop into multiple cell types that organize into ...
Aug 4, 2015
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Recent investigations have shown that our genome and those of other mammals is partitioned into large functional units called topologically associated domains, or TADs for short. TADs are very long DNA sections containing ...
May 13, 2015
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Researchers at the Babraham Institute and the Francis Crick Institute have developed and used a new technique to join the dots in the genomic puzzle. Just as a dot to dot puzzle needs to be completed to visualise the full ...
May 4, 2015
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Thousands of genetic "dimmer" switches, regions of DNA known as regulatory elements, were turned up high during human evolution in the developing cerebral cortex, according to new research from the Yale School of Medicine.
Mar 5, 2015
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There are roughly 20,000 genes and thousands of other regulatory "elements" stored within the three billion letters of the human genome. Genes encode information that is used to create proteins, while other genomic elements ...
Nov 10, 2014
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A single-letter change in the genetic code is enough to generate blond hair in humans, in dramatic contrast to our dark-haired ancestors. A new analysis by Howard Hughes Medical Institute (HHMI) scientists has pinpointed ...
Jun 1, 2014
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Variations in non-coding sections of the genome might be important contributors to type 2 diabetes risk, according to a new study.
Jan 12, 2014
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(Medical Xpress)—Researchers at the Wellcome Trust Sanger Institute and University of Cambridge have unpicked genetic variants that affect the formation of blood cells. They found that around a third of the variants play ...
Apr 17, 2013
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