In one of the first genome-wide studies to hunt for both genes and their regulatory "tags" in patients suffering from a common disease, researchers have found a clear role for the tags in mediating genetic risk for rheumatoid ...
Jan 20, 2013
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The parasitic disease leishmaniasis is found primarily in Central and South America, the Mediterranean region, the Middle East, and Central Asia and is transmitted to humans by a sand fly. An estimated 1.5 million new cases ...
Oct 24, 2023
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Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 million base pairs away from ...
May 8, 2023
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Though underlying medical conditions play an important role, many aspects of why COVID-19 severity can differ vastly from one patient to another have remained unclear.
May 19, 2022
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Researchers at Uppsala University have developed a method for identifying functional mutations and their effect on genes relevant to the development of glioblastoma—a malignant brain tumor with a very poor prognosis. The ...
Jun 9, 2020
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A large-scale study provides new insights into the mechanisms that can lead to cancer. It can happen when genes mutate, but cancer also can occur when the genetic regions involved in regulating gene expression change. In ...
Jul 10, 2018
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Scientists have long tried to pin down the causes of autism spectrum disorder. Recent studies have expanded the search for genetic links from identifying genes toward epigenetics, the study of factors that control gene expression ...
Jan 16, 2018
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Cells face a daunting task. They have to neatly pack a several meter-long thread of genetic material into a nucleus that measures only five micrometers across. This origami creates spatial interactions between genes and their ...
Mar 8, 2017
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In people with chronic infections or cancer, disease-fighting T cells tend to behave like an overworked militia - wheezing, ill-prepared, tentative - in a state of "exhaustion" that allows disease to persist. In a paper posted ...
Oct 27, 2016
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UCLA scientists have made a major advance in understanding the biology of schizophrenia. Using a recently developed technology for analyzing DNA, the scientists found dozens of genes and two major biological pathways that ...
Oct 19, 2016
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