Diseases, Conditions, Syndromes

Measles vaccination: 'All for one and one for all'

Measles was declared eradicated in the United States in 2000, but has reappeared in recent months in the form of outbreaks in several states. Of the 704 people in the U.S. infected with this highly contagious virus in 2019, ...

Medical research

A cell atlas of the aging lung

Aging promotes lung function decline and increases susceptibility to diseases of the respiratory tract. In order to understand these effects in detail, researchers at Helmholtz Zentrum München, a partner in the German Center ...

Medical research

Searching for side effects

Extracting relevant information from the scientific literature about side effects and adverse drug reactions to pharmaceutical products is an important part of data mining in this area. Writing in the International Journal ...

Medications

Empagliflozin in type 2 diabetes: Added benefit not proven

Empagliflozin (trade name Jardiance) has been approved since May 2014 for adults with type 2 diabetes mellitus in whom diet and exercise alone do not provide adequate glycaemic control. The German Institute for Quality and ...

Oncology & Cancer

Genetic make-up of rare gastrointestinal tract tumour decoded

Gastrointestinal stromal tumours (GIST) are relatively rare tumours of the gastrointestinal tract that can occur both as a harmless incidental finding and as aggressive, malignant disease. Two key genetic mutations that can ...

Oncology & Cancer

Added benefit of ingenol mebutate is not proven

The drug ingenol mebutate (trade name: Picato) has been approved in Germany since November 2012 as a gel for the treatment of certain forms of actinic keratosis in adults. In an early benefit assessment pursuant to the Act ...

Medications

Added benefit of saxagliptin/metformin combination is not proven

The fixed combination of the drugs saxagliptin and metformin (Komboglyze) has been approved in Germany since November 2011 for the treatment of type 2 diabetes mellitus. In an early benefit assessment pursuant to the "Act ...