An international collaboration steered by David Cortez, Richard N. Armstrong, Ph.D. Chair for Innovation in Biochemistry, explored how cells tolerate DNA damage and genome instability—and they arrived at conclusions that ...
May 3, 2023
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Researchers have uncovered a novel pathway that explains how cancer cells become resistant to chemotherapies, which in turn offers a potential solution for preventing chemo-resistance.
Sep 20, 2022
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A new study has uncovered a previously unknown role for the enzyme EXD2, identifying it as a potential drug target for cancer therapy.
Dec 19, 2019
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A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes. The findings, ...
Jul 20, 2016
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Cancer is caused by the growth of an abnormal cell which harbours DNA mutations, "copy errors" occurring during the DNA replication process. If these errors do take place quite regularly without having any damaging effect ...
Jan 22, 2016
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Cell duplication and growth is essential to sustaining life, and in order for this critical function to take place, cells must unwind the tight ball of DNA in their nucleus and then duplicate their genomic information. This ...
Jul 10, 2015
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Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population, often causing breast or ovarian cancer in young women of child-bearing ...
Apr 28, 2014
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