Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type ...
Nov 28, 2017
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Methicillin resistant Staphylococcus aureus (MRSA) emerged long before the introduction of the antibiotic methicillin into clinical practice, according to a study published in the open access journal Genome Biology. It was ...
Jul 19, 2017
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Investigators at the Massachusetts General Hospital (MGH) Cancer Center have identified the first genetic mechanisms conferring acquired resistance to a promising group of targeted cancer drugs. In a paper appearing in the ...
Mar 23, 2017
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The genetic mutations underlying treatment resistance in non-small cell lung cancer (NSCLC) are more complex and dynamic than previously thought. Analysis of 355 biopsied tumors from patients who acquired resistance to EGFR ...
Mar 16, 2017
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Epithelial ovarian cancer (EOC) is the most lethal disease among gynecologic malignancies. Patients with an advanced disease often relapse due to the development of chemoresistance. Chemotherapy failure is a consequence of ...
Jun 16, 2016
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A University of Colorado Cancer Center study presented at the American Association for Cancer Research Annual Meeting 2016 pinpoints ways that cancer cells evolve to resist the drug LOXO-101, a kinase inhibitor of the TRK-fusion ...
Apr 18, 2016
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Women with polycystic ovary syndrome (PCOS) have high levels of androgens in their blood, which has been assumed able to affect fetal development during pregnancy. An international team of researchers led from Karolinska ...
Nov 2, 2015
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Sleeping sickness, or African trypanosomiasis, is caused by trypanosome parasites transmitted by tsetse flies and threatens millions of people in sub-Saharan Africa. The disease is considered fatal if untreated, but as it ...
Jun 25, 2015
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A Yale-led research team has identified the molecular mechanism by which insulin normally inhibits production of glucose by the liver and why this process stops working in patients with type 2 diabetes, leading to hyperglycemia.
Feb 5, 2015
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A new screening platform using cells grown directly from tumor biopsy samples may lead to truly individualized treatment strategies that would get around the problem of treatment resistance, which limits the effectiveness ...
Nov 13, 2014
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