Diseases, Conditions, Syndromes

MICs of isoniazid, rifampin may predict tuberculosis relapse

(HealthDay)—In pretreatment isolates of Mycobacterium tuberculosis, higher minimum inhibitory concentrations (MICs) of isoniazid and rifampin below the standard resistance breakpoint are associated with increased risk of ...

Medical research

Researchers determine structure of tuberculosis drug target

Rutgers University scientists have determined the three-dimensional structure of the target of the first-line anti-tuberculosis drug rifampin. They have also discovered a new class of potential anti-tuberculosis drugs that ...

Diseases, Conditions, Syndromes

Experts warn of untreatable TB risk

Disease experts called Sunday for decisive leadership and more research funding to fend off the "very real" risk of an untreatable strain of tuberculosis (TB) emerging as more and more people develop resistance to existing ...

Diseases, Conditions, Syndromes

Researchers Identify Tuberculosis Strain That Thrives on Antibiotic

(PhysOrg.com) -- Scientists have identified a strain of antibiotic-resistant tuberculosis that thrives in the presence of rifampin, a front-line drug in the treatment of tuberculosis. The bacterium was identified in a patient ...

Medications

Rifampin kinetics poor in children

Rifampin (RMP), a first-line antituberculosis drug, reaches serum concentrations well below suggested lower limits when a standard dose of 8-12mg/kg body weight is given to children. A pharmacokinetic study, published in ...