Immunology

Genetic risk for lupus tied to ancestry

Northwestern Medicine collaborated with international colleagues in a study that identified two dozen new genes linked to lupus after analyzing genetic samples from over 27,000 individuals across the globe.

Arthritis & Rheumatism

Researchers reveal how receptor TLR-9 protects against lupus

When the pathogen-sensing intracellular receptors TLR-7 and TLR-9 were implicated in systemic lupus erythematosus (SLE), it was suspected that their removal would lessen the severity of the disease. However, while this held ...

Genetics

How a single faulty gene can lead to lupus

A research team at the Academy of Immunology and Microbiology, within the Institute for Basic Science (IBS) & Pohang University of Science and Technology (POSTECH) in South Korea has discovered the role of a key gene involved ...

Immunology

Researchers use blood serum markers to develop lupus risk index

Researchers at the Feinstein Institute for Medical Research, USA have developed an index that identifies the risk for lupus based on the presence and amount of Immunoglobin G (IgG) and Immunoglobin M (IgM) antibodies and ...

Arthritis & Rheumatism

Alterations in soluble mediators predict transition to SLE

(HealthDay)—For unaffected relatives of systemic lupus erythematosus (SLE) patients, preclinical alterations in levels of soluble mediators may predict transition to disease, according to a study published in the March ...

Immunology

Study reveals role for oxidized mitochondrial DNA in lupus

Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus (SLE) patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune ...

Arthritis & Rheumatism

Metabolic syndrome common in young women with lupus

(HealthDay)—Metabolic syndrome is common in young, premenopausal women with systemic lupus erythematosus (SLE), and chloroquine appears to protect against metabolic syndrome in these women, according to a study published ...

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