Medical research

New insights into sodium channel structure

Northwestern Medicine scientists have mapped the complete structure of a voltage-gated sodium channel, proteins in the membrane of cells that play an important role in many diseases. The findings were published in Nature ...

Medical research

Prospect for more effective treatment of nerve pain

Trigeminal neuralgia is characterized by sharp, lancinating pain in the teeth or facial area. The standard treatment for this chronic nerve pain can cause burdening side effects. A novel substance inhibits the pain effectively ...

Neuroscience

Regulating sodium channels in epilepsy

A new Northwestern Medicine study may help explain why patients with the same epilepsy gene mutation experience different levels of disease severity. The findings, published in the Proceedings of the National Academy of Sciences ...

Cardiology

Cause of heart arrhythmia in adult muscular dystrophy clarified

An international joint research group found that the cause of heart arrhythmia in myotonic dystrophy was RNA abnormalities in the sodium channel in the heart, clarifying the symptom's mechanism. This finding will be helpful ...

Medical research

No pain and extreme pain from one gene

The family from northern Pakistan is one of the strangest to appear in the scientific literature. At its center is a 10-year-old, a street performer who walked on hot coals and inserted daggers through his arms before astonished ...

Neuroscience

Two potential therapeutic avenues for spasticity

Following spinal cord injury, most patients experience an exaggeration of muscle tone called spasticity, which frequently leads to physical disability. A team at the Institut de Neurosciences de la Timone (CNRS/Aix-Marseille ...

Neuroscience

Researchers discover a new mechanism of epilepsy

In epilepsy, nerve cells lose their usual rhythm, and ion channels, which have a decisive influence on their excitability, are involved. A team of researchers under the direction of the University of Bonn has now discovered ...

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